MOLB 7950: Informatics and Statistics for Molecular Biology
This page contains an outline of the topics, content, and assignments for the semester. Note that this schedule will be updated as the semester progresses, with all changes documented here.
| MOLB 7950 - Fall 2025 Schedule | ||||||||||
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| Classes held in-person from 9:00-10:30am in AHSB 2201 | ||||||||||
| Date | Block | Topic | Instructor | Title |
Links
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| Prepare | Slides | Exercises | HW | Key | ||||||
| Week 1 | ||||||||||
| 01 | Mon, Aug 25, 2025 | Bootcamp | R | Hesselberth | Intro to R & RStudio | 📖 | 📃 | 💪 | . | . |
| 02 | Tue, Aug 26, 2025 | Bootcamp | R | Hesselberth | Tidy data & tidyr | . | . | . | . | . |
| 03 | Wed, Aug 27, 2025 | Bootcamp | R | Hesselberth | dplyr | . | . | . | . | . |
| 04 | Thu, Aug 28, 2025 | - | - | - | NO CLASS: LABOR DAY | . | . | . | . | . |
| 05 | Fri, Aug 29, 2025 | Bootcamp | R | Hesselberth | ggplot2 | . | . | . | . | . |
| Week 2 | ||||||||||
| 06 | Mon, Sep 1, 2025 | Bootcamp | R | Hesselberth | ggplot2 | . | . | . | . | . |
| 07 | Tue, Sep 2, 2025 | Bootcamp | R | Hesselberth | tidyverse odds & ends | . | . | . | . | . |
| 08 | Wed, Sep 3, 2025 | Bootcamp | R | Hesselberth | putting it all together | . | . | . | . | . |
| 09 | Thu, Sep 4, 2025 | Bootcamp | R | Hesselberth | putting it all together | . | . | . | . | . |
| 10 | Fri, Sep 5, 2025 | Bootcamp | Statistics | Mukherjee | Stats intro and history | . | . | . | . | . |
| Week 3 | ||||||||||
| 11 | Mon, Sep 8, 2025 | Bootcamp | Statistics | Mukherjee | Probability and descriptive stats | . | . | . | . | . |
| 12 | Tue, Sep 9, 2025 | Bootcamp | Statistics | Mukherjee | Hypothesis testing | . | . | . | . | . |
| 13 | Wed, Sep 10, 2025 | Bootcamp | Statistics | Mukherjee | Hypothesis testing | . | . | . | . | . |
| 14 | Thu, Sep 11, 2025 | Bootcamp | Statistics | Mukherjee | Exploratory data analysis | . | . | . | . | . |
| 15 | Fri, Sep 12, 2025 | Bootcamp | Statistics | Mukherjee | Big data concerns | . | . | . | . | . |
| Week 4 | ||||||||||
| 16 | Mon, Sep 15, 2025 | DNA | Mapping chromatin structure and transactions | Hesselberth | Experimental overview | . | . | . | . | . |
| 17 | Wed, Sep 17, 2025 | DNA | Chromatin-centric methods | Hesselberth | Information from fragment length distributions | . | . | . | . | . |
| 18 | Fri, Sep 19, 2025 | DNA | Chromatin-centric methods | Hesselberth | Meta-plots and heatmaps | . | . | . | . | . |
| Week 5 | ||||||||||
| 19 | Mon, Sep 22, 2025 | DNA | Where do proteins bind in the genome? | Hesselberth | Experimental overview | . | . | . | . | . |
| 20 | Wed, Sep 24, 2025 | DNA | Factor-centric methods | Hesselberth | Peak calling | . | . | . | . | . |
| 21 | Fri, Sep 26, 2025 | DNA | Factor-centric methods | Hesselberth | Sequence motif analysis | . | . | . | . | . |
| Week 6 | ||||||||||
| 22 | Mon, Sep 29, 2025 | RNA | RNA-seq Overview | Mukherjee | Concepts and techniques | . | . | . | . | . |
| 23 | Wed, Oct 1, 2025 | RNA | Import, filtering, QC | Mukherjee | metrics and sample similarity | . | . | . | . | . |
| 24 | Fri, Oct 3, 2025 | RNA | Differential Gene Expression | Mukherjee | DESeq2 | . | . | . | . | . |
| Week 7 | ||||||||||
| 25 | Mon, Oct 6, 2025 | RNA | Alternative Splicing | Mukherjee | rMATS | . | . | . | . | . |
| 26 | Wed, Oct 8, 2025 | RNA | Review Proposals | Hesselberth | Review Proposals | . | . | . | . | . |
| 27 | Fri, Oct 10, 2025 | RNA | RBP-RNA 1 | Mukherjee | CLIP-seq | . | . | . | . | . |
| Week 8 | ||||||||||
| 28 | Mon, Oct 13, 2025 | RNA | RBP-RNA 2 | Mukherjee | Data integrations | . | . | . | . | . |
| 29 | Wed, Oct 15, 2025 | RNA | Long-read sequencing | Hesselberth | - | . | . | . | . | . |
| 30 | Fri, Oct 17, 2025 | - | - | - | NO CLASS: CSDV RETREAT | . | . | . | . | . |
| Week 9 | ||||||||||
| 31 | Mon, Oct 20, 2025 | RNA | Single-cell | Wells-Wrasman | - | . | . | . | . | . |
| 32 | Wed, Oct 22, 2025 | RNA | Single-cell | Wells-Wrasman | - | . | . | . | . | . |
| 33 | Fri, Oct 24, 2025 | - | - | - | NO CLASS: MOLB RETREAT | . | . | . | . | . |
| Week 10 | ||||||||||
| 34 | Mon, Oct 27, 2025 | Final | - | - | Final project presentations | . | . | . | . | . |
| 35 | Wed, Oct 29, 2025 | Final | - | - | Final project presentations | . | . | . | . | . |